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Ikaros (C-terminus) Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
  • 1 - Ikaros (C-terminus) Antibody AP52711
    Western blot detection of Ikaros(C-terminus) in Ramos and Jurkat cell lysates using Ikaros(C-terminus) mouse mAb (1:1000 diluted).Predicted band size: 58KDa.Observed band size: 58KDa.
  • 5 - Ikaros (C-terminus) Antibody AP52711
    Immunoprecipitation analysis of Hela cell lysate using Ikaros (C-terminus) mouse mAb.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IP
Primary Accession Q13422
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Calculated MW 58 KDa
Additional Information
Gene ID 10320
Other Names CLL associated antigen KW 6;DNA-binding protein Ikaros;hIk 1;hIk-1;Hs.54452;IK1;Ikaros (zinc finger protein);IKAROS;IKAROS family zinc finger 1 (Ikaros);Ikaros family zinc finger protein 1;Ikzf1;IKZF1_HUMAN;LYF1;Lymphoid transcription factor LyF-1;PRO0758;Zinc finger protein subfamily 1A 1 (Ikaros);zinc finger protein subfamily 1A 1;Zinc finger protein, subfamily 1A, member 1;ZNFN1A1.
Dilution WB~~1:1000
IP~~0.38888888888889
Format Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.02% sodium azide, 50%,glycerol
Storage Store at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name IKZF1
Synonyms IK1, IKAROS, LYF1, ZNFN1A1
Function Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Binds with higher affinity to gamma satellite A. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (terminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity).
Cellular Location Nucleus. Note=In resting lymphocytes, distributed diffusely throughout the nucleus. Localizes to pericentromeric heterochromatin in proliferating cells. This localization requires DNA binding which is regulated by phosphorylation / dephosphorylation events (By similarity). Isoform Ik6: Cytoplasm.
Tissue Location Abundantly expressed in thymus, spleen and peripheral blood Leukocytes and lymph nodes. Lower expression in bone marrow and small intestine
Research Areas

BACKGROUND

Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Binds with higher affinity to gamma satellite A. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (terminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity).

REFERENCES

Nietfeld W.,et al.Immunol. Lett. 49:139-141(1996).
Molnar A.,et al.J. Immunol. 156:585-592(1996).
Sanchez-Tapia E.M.,et al.Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Kalnine N.,et al.Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.

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