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FOXP3 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
  • 1 - FOXP3 Antibody AP52710
    Western blot detection of FOXP3 in CHO-K1 cell lysate(A)and CHO-K1 transfected by FOXP3(B)cell lysate using FOXP3 mouse mAb (1:300 diluted).Predicted band size:47KDa.Observed band size:50KDa.
  • 8 - FOXP3 Antibody AP52710
    Immunocytochemistry staining of CHO-K1 cells which transfected by FOXP3 fixed in 1% Paraformaldehyde and using anti-FOXP3 mouse mAb (dilution 1:100).
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, ICC
Primary Accession Q9BZS1
Host Mouse
Clonality Monoclonal
Isotype IgG1
Calculated MW 47 KDa
Additional Information
Gene ID 50943
Other Names AIID;DIETER;Forkhead box P3;Forkhead box protein P3;foxp3;foxp3;FOXP3_HUMAN;FOXP3delta7; Immune dysregulation polyendocrinopathy enteropathy X linked;Immunodeficiency polyendocrinopathy enteropathy X linked;IPEX;JM2;MGC141961;MGC141963; OTTHUMP00000025832;OTTHUMP00000025833;OTTHUMP00000226737;PIDX;SCURFIN;XPID.
Dilution WB~~1:300
ICC~~1:100
Format Ascites containing with 0.02% sodium azide and 50% glycerol.
Storage Store at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name FOXP3
Synonyms IPEX
Function Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon- gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2 (PubMed:15790681). Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7 (PubMed:17360565). Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1 (PubMed:17377532). Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development (PubMed:18368049). Inhibits the transcriptional activator activity of RORA (PubMed:18354202). Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4 (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00089, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:18354202, ECO:0000269|PubMed:22678915, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:23973222, ECO:0000269|PubMed:23973223}. Cytoplasm. Note=Predominantly expressed in the cytoplasm in activated conventional T-cells whereas predominantly expressed in the nucleus in regulatory T-cells (Treg). The 41 kDa form derived by proteolytic processing is found exclusively in the chromatin fraction of activated Treg cells (By similarity) {ECO:0000250|UniProtKB:Q99JB6, ECO:0000269|PubMed:22678915}
Research Areas

BACKGROUND

Probable transcription factor. Plays a critical role in the control of immune response.

REFERENCES

Brunkow M.E.,et al.Nat. Genet. 27:68-73(2001).
Wang J.,et al.Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
Kaur G.,et al.Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
Lin L.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Ross M.T.,et al.Nature 434:325-337(2005).

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