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Keratin 18 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
  • 1 - Keratin 18 Antibody AP52707
    Western blot detection of Keratin 18 in Hela,COS7 and 293T cell lysates using Keratin 18 mouse mAb (1:2000 diluted).Predicted band size:46KDa.Observed band size:46KDa.
  • 8 - Keratin 18 Antibody AP52707
    Immunocytochemistry staining of HeLa cells fixed by anhydrous methanol for 2 h at -20℃ and using anti-Keratin 18 mouse mAb (dilution 1:800).
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, ICC
Primary Accession P05783
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2a
Calculated MW 46 KDa
Additional Information
Gene ID 3875
Other Names Cell proliferation inducing gene 46 protein;Cell proliferation inducing protein 46;Cell proliferation-inducing gene 46 protein;CK 18;CK-18;CK18;Cytokeratin 18;Cytokeratin endo B;Cytokeratin-18;Cytokeratin18;K 18;K18;K1C18_HUMAN;Keratin 18;Keratin D;Keratin type I cytoskeletal 18;keratin, type I cytoskeletal 18;Keratin-18;Keratin18;Kerd;KRT18.
Dilution WB~~1:2000
ICC~~1:800
Format Purified mouse monoclonal in PBS(pH 7.4) containing with 0.02% sodium azide,0.1mg/mlBSA and 50% glycerol.
Storage Store at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name KRT18
Synonyms CYK18
Function Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
Cellular Location Cytoplasm, perinuclear region. Nucleus, nucleolus
Tissue Location Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.
Research Areas

BACKGROUND

Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.

REFERENCES

Oshima R.G.,et al.Differentiation 33:61-68(1986).
Kim J.W.,et al.Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Kulesh D.A.,et al.Mol. Cell. Biol. 8:1540-1550(1988).

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