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Integrin beta 3(N-terminus) Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
  • 1 - Integrin beta 3(N-terminus) Antibody AP52700
    Western blot detection of Integrin beta 3(N-terminus) in 15ug and 25ug Leukocyte whole cell lysate using Integrin beta 3(N-terminus) mouse mAb (1:1000 diluted).Predicted band size:110KDa.Observed band size:110KDa.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P05106
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Calculated MW 110 KDa
Additional Information
Gene ID 3690
Other Names BDPLT2;CD 61;CD61;CD61 antigen;GP3A;GPIIIa;GT;HPA 1;HPA 4;Integrin beta 3 (platelet glycoprotein IIIa antigen CD61);Integrin beta chain beta 3;Integrin beta-3;ITB3_HUMAN; ITG B3;ITGB 3;ITGB3;NAIT;Platelet fibrinogen receptor beta subunit;Platelet glycoprotein IIIa;platelet glycoprotein IIIa precursor;Platelet membrane glycoprotein IIIa;PTP.
Dilution WB~~1:1000
Format Purified mouse monoclonal in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Storage Store at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name ITGB3
Synonyms GP3A
Function Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha- IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
Cellular Location Cell membrane; Single- pass type I membrane protein. Cell projection, lamellipodium membrane Cell junction, focal adhesion
Tissue Location Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis
Research Areas

BACKGROUND

Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha- IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

REFERENCES

Fitzgerald L.A.,et al.J. Biol. Chem. 262:3936-3939(1987).
Zimrin A.B.,et al.J. Clin. Invest. 81:1470-1475(1988).
Frachet P.,et al.Mol. Biol. Rep. 14:27-33(1990).
Kumar C.S.,et al.J. Biol. Chem. 272:16390-16397(1997).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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