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TBLR1 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
  • 1 - TBLR1 Antibody AP52686
    Western blot detection of TBLR1 in Mouse brain,Mouse heart and K562 cell lysates using TBLR1 mouse mAb (1:1000 diluted).Predicted band size: 60KDa.Observed band size: 60Kda.
  • 8 - TBLR1 Antibody AP52686
    Immunocytochemistry staining of HeLa cells fixed with 4% Paraformaldehyde and using TBLR1 mouse mAb (dilution 1:200).
  • 2 - TBLR1 Antibody AP52686
    IHC of paraffin-embedded huma breast cancer using anti-TBLR1 mouse mAb diluted 1/500-1/1000
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, ICC, IHC
Primary Accession Q9BZK7
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Isotype IgG1
Calculated MW 60 KDa
Additional Information
Gene ID 79718
Other Names C21;DC42;F box like/WD repeat containing protein TBL1XR1;F-box-like/WD repeat-containing protein TBL1XR1;FLJ12894;IRA1;Nuclear receptor corepressor/HDAC3 complex subunit;Nuclear receptor corepressor/HDAC3 complex subunit TBLR1;TBL1 related protein 1;TBL1-related protein 1;TBL1R_HUMAN;TBL1XR1;Transducin (beta) like 1 X linked receptor 1;Transducin beta like 1X related protein 1;Transducin beta-like 1X-related protein 1.
Dilution WB~~1:1000
ICC~~1:200
IHC~~1:100
Format Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.02% sodium azide, 50%,glycerol
Storage Store at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name TBL1XR1
Synonyms IRA1, TBLR1
Function F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.
Cellular Location Nucleus.
Tissue Location Ubiquitous.
Research Areas

BACKGROUND

F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.

REFERENCES

Zhang J.,et al.Mol. Cell 9:611-623(2002).
Zhang X.,et al.Exp. Hematol. 28:1286-1296(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Yoon H.-G.,et al.EMBO J. 22:1336-1346(2003).

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