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TBLR1 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
  • 1 - TBLR1 Antibody AP52686
    Western blot detection of TBLR1 in Mouse brain,Mouse heart and K562 cell lysates using TBLR1 mouse mAb (1:1000 diluted).Predicted band size: 60KDa.Observed band size: 60Kda.
  • 8 - TBLR1 Antibody AP52686
    Immunocytochemistry staining of HeLa cells fixed with 4% Paraformaldehyde and using TBLR1 mouse mAb (dilution 1:200).
  • 2 - TBLR1 Antibody AP52686
    IHC of paraffin-embedded huma breast cancer using anti-TBLR1 mouse mAb diluted 1/500-1/1000
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, ICC, IHC
Primary Accession Q9BZK7
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Isotype IgG1
Calculated MW 60 KDa
Additional Information
Gene ID 79718
Other Names C21;DC42;F box like/WD repeat containing protein TBL1XR1;F-box-like/WD repeat-containing protein TBL1XR1;FLJ12894;IRA1;Nuclear receptor corepressor/HDAC3 complex subunit;Nuclear receptor corepressor/HDAC3 complex subunit TBLR1;TBL1 related protein 1;TBL1-related protein 1;TBL1R_HUMAN;TBL1XR1;Transducin (beta) like 1 X linked receptor 1;Transducin beta like 1X related protein 1;Transducin beta-like 1X-related protein 1.
Dilution WB~~1:1000
ICC~~1:200
IHC~~1:100
Format Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.02% sodium azide, 50%,glycerol
Storage Store at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name TBL1XR1
Synonyms IRA1, TBLR1
Function F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.
Cellular Location Nucleus.
Tissue Location Widely expressed including the pituitary, hypothalamus, white and brown adipose tissue, muscle and liver
Research Areas

BACKGROUND

F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.

REFERENCES

Zhang J.,et al.Mol. Cell 9:611-623(2002).
Zhang X.,et al.Exp. Hematol. 28:1286-1296(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Yoon H.-G.,et al.EMBO J. 22:1336-1346(2003).

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