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>   首页   >   产品   >   一抗   >   精选抗体   >   磷酸化抗体   >   MEF2C (Phospho-Ser396) Antibody   

MEF2C (Phospho-Ser396) Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - MEF2C (Phospho-Ser396) Antibody AP52595
    Western blot analysis of extracts from 3T3 cells, treated with starved (24hours), using MEF2C (Phospho-Ser396) antibody.
  • 1 - MEF2C (Phospho-Ser396) Antibody AP52595
    Western blot analysis of extracts from cos-7 cells (Lane 2), using MEF2C (Phospho-Ser396) Antibody. The lane on the left is treated with synthesized peptide.
  • 2 - MEF2C (Phospho-Ser396) Antibody AP52595
    Immunohistochemistry analysis of paraffin-embedded human brain tissue using MEF2C (Phospho-Ser396) antibody.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC
Primary Accession Q06413
Host Rabbit
Clonality Polyclonal
Calculated MW 51221 Da
Additional info
Gene ID 4208
Other Names Myocyte-specific enhancer factor 2C, MEF2C
Dilution WB~~1:1000
IHC~~1:50~100
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name MEF2C
Function Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.
Cellular Location Nucleus.
Tissue Location Expressed in brain and skeletal muscle.
Research Areas

BACKGROUND

Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.

REFERENCES

Leifer D.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:1546-1550(1993).
McDermott J.C.,et al.Mol. Cell. Biol. 13:2564-2577(1993).
Infantino V.,et al.Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Schmutz J.,et al.Nature 431:268-274(2004).

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