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>   首页   >   产品   >   一抗   >   精选抗体   >   磷酸化抗体   >   GR (Phospho-Ser203) Antibody   

GR (Phospho-Ser203) Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - GR (Phospho-Ser203) Antibody AP52488
    Western blot analysis of extracts from A549 cells, treated with dexamethason (10 nM, 1 hour), using GR (Phospho-Ser203) antibody.
  • 1 - GR (Phospho-Ser203) Antibody AP52488
    Western blot analysis of extracts from Hela cells (Lane 2) and Hepg2 cells (Lane 3), using GR (Phospho-Ser203) Antibody. The lane on the left is treated with synthesized peptide.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P04150
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 85659 Da
Additional info
Gene ID 2908
Other Names Glucocorticoid receptor, GR, Nuclear receptor subfamily 3 group C member 1, NR3C1, GRL
Dilution WB~~1:1000
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name NR3C1
Synonyms GRL
Function Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression.
Cellular Location Cytoplasm. Mitochondrion. Nucleus Note=Cytoplasmic in the absence of ligand, nuclear after ligand- binding
Tissue Location Widely expressed. In the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart.
Research Areas

BACKGROUND

Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression.

REFERENCES

Hollenberg S.M.,et al.Nature 318:635-641(1985).
Encio I.J.,et al.J. Biol. Chem. 266:7182-7188(1991).
Wang W.,et al.Nucleic Acids Res. 39:44-58(2011).
Turner J.D.,et al.Ann. N. Y. Acad. Sci. 1095:334-341(2007).
Munroe D.G.,et al.Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases.

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