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Rabbit Anti-Tp73 protein Polyclonal Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - Rabbit Anti-Tp73 protein Polyclonal Antibody AP52324
    Mouse Kidney lysates probed with Rabbit Anti-Tp73 Polyclonal Antibody, Unconjugated (AP52324) at 1:300 overnight at 4˚C. Incubate with HRP conjugated Goat-Anti-Rabbit IgG at 1: 5000 for 90min at 37˚C.
  • 14 - Rabbit Anti-Tp73 protein Polyclonal Antibody AP52324
    Formalin-fixed and paraffin embedded mouse brain labeled with Rabbit Anti-P73 protein Polyclonal Antibody, Unconjugated (AP52324) at 1:200 followed by conjugation to the secondary antibody and DAB staining
  • 14 - Rabbit Anti-Tp73 protein Polyclonal Antibody AP52324
    Formalin-fixed and paraffin embedded human endometrium tissue labeled with Anti-P73 Polyclonal Antibody, Unconjugated (AP52324) followed by conjugation to the secondary antibody and DAB staining
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IF, IHC-P
Primary Accession Q9JJP2
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 69096 Da
Additional info
Gene ID 22062
Other Names p73; Tp73; TAp73; Tumor protein p73; p53-like transcription factor; p53-related protein; Trp73
Dilution WB~~1:100~1:500
IHC-P~~1:100~1:500
Format0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
StorageStore at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Protein Information
Name Tp73
Function Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.
Cellular Location Nucleus. Cytoplasm. Note=Accumulates in the nucleus in response to DNA damage.
Tissue Location Found in striatal neurons of mutant huntingtin (htt) transgenic mice (at protein level). Isoform 1 is expressed in the nasal epithelium, the vomeronasal organ, the hippocampus and the hypothalamus.
Research Areas

BACKGROUND

Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.

REFERENCES

Yang A.,et al.Nature 404:99-103(2000).
Carninci P.,et al.Science 309:1559-1563(2005).
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Herranz M.,et al.Cancer Res. 59:2068-2071(1999).

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