Rabbit Anti-NADPH oxidase 4 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application ![]()
| WB, IF, IHC-P |
---|---|
Primary Accession | Q9JHI8 |
Reactivity | Human, Mouse, Rat, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 66519 Da |
Gene ID | 50490 |
---|---|
Other Names | AI64821; NADPH oxidase 4; Kidney oxidase-1; KOX-1; Kidney superoxide-producing NADPH oxidase; Renal NAD(P)H-oxidase; Superoxide-generating NADPH oxidase 4; Nox4; Renox |
Dilution | IHC-P~~1:100~1:500 WB~~1:100~1:500 |
Format | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce |
Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
Name | Nox4 |
---|---|
Synonyms | Renox |
Function | Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. |
Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell junction, focal adhesion. Cell membrane. Note=May localize to plasma membrane and focal adhesions. |
Tissue Location | EXpressed in brain, in all layers of the cerebellum, in pyramidal cells of the Ammon horn and in Purkinje cells (at protein level). Expressed in osteoclasts, leukocytes, kidney, liver and lung. |
BACKGROUND
Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB.
REFERENCES
Geiszt M.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:8010-8014(2000).
Shiose A.,et al.J. Biol. Chem. 276:1417-1423(2001).
Yang S.,et al.J. Biol. Chem. 276:5452-5458(2001).
Banfi B.,et al.Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
Carninci P.,et al.Science 309:1559-1563(2005).

终于等到您。感谢您使用ABGENT(百奇生物)抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息,您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。
如有疑问,联系:0512-69552906 tech.abgent@wuxiapptec.com.