|Application ||WB, IF, IHC-P|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||43770 Da|
|Other Names||WNT13; Protein Wnt-2b; Protein Wnt-13; WNT2B|
|Format||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce|
|Storage||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
|Function||Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta- catenin signaling pathway. Plays a redundant role in embryonic lung development.|
|Cellular Location||Secreted, extracellular space, extracellular matrix. Secreted|
|Tissue Location||Isoform 1 is expressed in adult heart, brain, placenta, lung, prostate, testis, ovary, small intestine and colon. In the adult brain, it is mainly found in the caudate nucleus, subthalamic nucleus and thalamus. Also detected in fetal brain, lung and kidney. Isoform 2 is expressed in fetal brain, fetal lung, fetal kidney, caudate nucleus, testis and cancer cell lines.|
Provided below are standard protocols that you may find useful for product applications.
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. May be involved in normal development or differentiation as well as in carcinogenesis.
Katoh M.,et al.Oncogene 13:873-876(1996).
Katoh M.,et al.Biochem. Biophys. Res. Commun. 275:209-216(2000).
Gregory S.G.,et al.Nature 441:315-321(2006).
Bergstein I.,et al.Genomics 46:450-458(1997).
Picariello G.,et al.Proteomics 8:3833-3847(2008).