Rabbit Anti-CD34 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application ![]()
| WB, IF, ICC, IHC-P |
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Primary Accession | Q64314 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Gene ID | 12490 |
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Other Names | AU496; Hematopoietic progenitor cell antigen CD34; CD34 |
Dilution | WB~~1/100~1/500 IHC-P~~1/100~1/500 IF~~1/100~1/200 |
Format | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce |
Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
Name | Cd34 |
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Function | Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins (By similarity). |
Cellular Location | Membrane; Single-pass type I membrane protein |
Tissue Location | Highly expressed in hematopoietic progenitor cell lines, brain and testis, and moderately in the thymus, spleen, and bone marrow, but not in adult liver |
BACKGROUND
Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins (By similarity).
REFERENCES
Brown J.,et al.Int. Immunol. 3:175-184(1991).
Suda J.,et al.Blood 79:2288-2295(1992).
Rush J.,et al.Nat. Biotechnol. 23:94-101(2005).
Cao L.,et al.J. Immunol. 179:5864-5876(2007).
Gundry R.L.,et al.Mol. Cell. Proteomics 8:2555-2569(2009).

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