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>   首页   >   产品   >   一抗   >   癌症   >   Rabbit Anti-Caveolin-1 Polyclonal Antibody   

Rabbit Anti-Caveolin-1 Polyclonal Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - Rabbit Anti-Caveolin-1 Polyclonal Antibody AP52245
    Lane 1: mouse lung lysates Lane 2: mouse muscle lysates probed with Anti Caveolin-1 Polyclonal Antibody, Unconjugated (AP52245) at 1:200 in 4˚C. Followed by conjugation to secondary antibody at 1:3000 90min in 37˚C. Predicted band 20kD. Observed band size: 20kD.
  • 14 - Rabbit Anti-Caveolin-1 Polyclonal Antibody AP52245
    Formalin-fixed and paraffin embedded mouse eye labeled with Anti Caveolin-1 Polyclonal Antibody, Unconjugated (AP52245) at 1:200 followed by conjugation to the secondary antibody and DAB staining.
  • 14 - Rabbit Anti-Caveolin-1 Polyclonal Antibody AP52245
    Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-Caveolin-1 Polyclonal Antibody, Unconjugated (AP52245) at 1:200 followed by conjugation to the secondary antibody and DAB staining.
  • 4 - Rabbit Anti-Caveolin-1 Polyclonal Antibody AP52245
    RSC96 cells probed with Caveolin-1 Polyclonal Antibody, Unconjugated (AP52245) at 1:100 for 30 minutes followed by incubation with a conjugated secondary (PE Conjugated) (green) for 30 minutes compared to control cells (blue), secondary only (light blue) and isotype control (orange).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
IF, IHC-P
Primary Accession Q03135
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 20472 Da
Additional info
Gene ID 857
Other Names CGL3; PPH3; BSCL3; LCCNS; VIP21; MSTP085; Caveolin-1; CAV1; CAV
Dilution WB~~1:100~1:500
IHC-P~~1:100~1:500
FC~~1:20~1:100
Format0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
StorageStore at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Protein Information
Name CAV1
Synonyms CAV
Function May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway.
Cellular Location Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein Membrane, caveola; Peripheral membrane protein. Membrane raft Note=Colocalized with DPP4 in membrane rafts. Potential hairpin- like structure in the membrane. Membrane protein of caveolae
Tissue Location Expressed in muscle and lung, less so in liver, brain and kidney
Research Areas

BACKGROUND

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway.

REFERENCES

Glenney J.R. Jr.,et al.FEBS Lett. 314:45-48(1992).
Hurlstone A.F.,et al.Oncogene 18:1881-1890(1999).
Engelman J.A.,et al.FEBS Lett. 448:221-230(1999).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Vainonen J.P.,et al.Biochem. Biophys. Res. Commun. 320:480-486(2004).

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