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Rabbit Anti-Bcl-2 (Ser70) Polyclonal Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 14 - Rabbit Anti-Bcl-2 (Ser70) Polyclonal Antibody AP52218
    Formalin-fixed and paraffin embedded rat kidney labeled with Rabbit Anti Phospho-Bcl-2(Ser70) Polyclonal Antibody, Unconjugated (AP52218) at 1:200 followed by conjugation to the secondary antibody and DAB staining
  • 1 - Rabbit Anti-Bcl-2 (Ser70) Polyclonal Antibody AP52218
    Mouse spleen lysates probed with Anti-Bcl-2 (Ser70) Polyclonal Antibody, Unconjugated (AP52218) at 1:300 in 4˚C. Followed by conjugation to secondary antibody at 1:5000 90min in 37˚C
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IF, ICC, IHC-P
Primary Accession P49950
Reactivity Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 26622 Da
Additional info
Gene ID 24224
Other Names Bcl-2; Apoptosis regulator Bcl-2; Bcl2
Dilution IHC-P~~1:100~1:500
WB~~1:100~1:500
Format0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
StorageStore at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Protein Information
Name Bcl2
Synonyms Bcl-2
Function Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
Cellular Location Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein Endoplasmic reticulum membrane; Single-pass membrane protein
Tissue Location Expressed in a variety of tissues, with highest levels in reproductive tissues. In the adult brain, expression is localized in mitral cells of the olfactory bulb, granule and pyramidal neurons of hippocampus, pontine nuclei, cerebellar granule neurons, and in ependymal cells. In prenatal brain, expression is higher and localized in the neuroepithelium and in the cortical plate
Research Areas

BACKGROUND

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).

REFERENCES

Sato T.,et al.Gene 140:291-292(1994).
Tilly J.L.,et al.Endocrinology 136:232-241(1995).
Castren E.,et al.Neuroscience 61:165-177(1994).
Eliseev R.A.,et al.J. Biol. Chem. 284:9692-9699(2009).

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