注册 | 登录
所有产品
  • 所有产品
  • 一抗
  • 裂解液
>   首页   >   产品   >   一抗   >   癌症   >   Rabbit Anti-TLR2 Polyclonal Antibody   

Rabbit Anti-TLR2 Polyclonal Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - Rabbit Anti-TLR2 Polyclonal Antibody AP52045
    L1 rat brain, L2 rat lung lysates probed (AP52045) at 1:200 in 4˚C. Followed by conjugation to secondary antibody at 1:3000 90min in 37˚C. Predicted and observed band size: 84kDa.
  • 14 - Rabbit Anti-TLR2 Polyclonal Antibody AP52045
    Formalin-fixed and paraffin embedded rat ovary tissue labeled with Rabbit Anti-TLR2/CD282 Polyclonal Antibody (AP52045), Unconjugated 1:200 followed by conjugation to the secondary antibody and DAB staining
  • 4 - Rabbit Anti-TLR2 Polyclonal Antibody AP52045
    Mouse spleen cells probed with TLR2 Polyclonal Antibody, Unconjugated AP52045 at 1:20 for 30 minutes followed by incubation with a conjugated secondary antibody (PE Conjugated) (green) for 30 minutes compared to control cells (blue), secondary only (light blue) and isotype control (orange).
  • 4 - Rabbit Anti-TLR2 Polyclonal Antibody AP52045
    Human A549 cells probed with TLR2 Polyclonal Antibody, Unconjugated AP52045 (green) at 1:20 for 30 minutes followed by a PE conjugated secondary antibody compared to unstained cells (blue), secondary only (light blue), and isotype control (orange).
  • 产品详情
  • 文献引用 : 1
  • 实验流程
  • 背景知识
Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IF, IHC-P
Primary Accession O60603
Reactivity Human, Mouse, Rat, Bovine
Host Rabbit
Clonality Polyclonal
Additional info
Gene ID 7097
Other Names TIL4; CD282; Toll-like receptor 2; Toll/interleukin-1 receptor-like protein 4; TLR2
Dilution WB~~1/100~1/500
IHC-P~~1/100~1/500
FC~~1/20~1/100
Format0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
StorageStore at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Protein Information
Name TLR2
Synonyms TIL4
Function Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues
Research Areas
Deletion of Thioredoxin-interacting protein ameliorates high fat diet-induced non-alcoholic steatohepatitis through modulation of Toll-like receptor 2-NLRP3-inflammasome axis: Histological and immunohistochemical study.
Author : Mohamed IN1,Sarhan NR2,Eladl MA3,El-Remessy AB4,El-Sherbiny M5.
Acta Histochem. 2018 Feb 23. pii: S0065-1281(17)30428-2. doi: 10.1016/j.acthis.2018.02.006. [Epub ahead of print]
29482933

BACKGROUND

Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.

REFERENCES

Chaudhary P.M.,et al.Blood 91:4020-4027(1998).
Rock F.L.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:588-593(1998).
Yang R.-B.,et al.Nature 395:284-288(1998).
Nakajima T.,et al.Immunogenetics 60:727-735(2008).
Georgel P.,et al.PLoS ONE 4:E7803-E7803(2009).

FeedBack

终于等到您。感谢您使用ABGENT(百奇生物)抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息,您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。

如有疑问,联系:0512-69552906 tech.abgent@wuxiapptec.com.


我要评价