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Apolipoprotein E Receptor 2 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - Apolipoprotein E Receptor 2 Antibody AP51925
    Jurkat
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q14114
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 126 KDa
Additional info
Gene ID 7804
Other Names Low-density lipoprotein receptor-related protein 8, LRP-8, Apolipoprotein E receptor 2, LRP8, APOER2
Target/Specificity KLH conjugated synthetic peptide derived from human Apolipoprotein E Receptor 2
Dilution WB~~1:500
Format 0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name LRP8
Synonyms APOER2
Function Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor.
Cellular Location Cell membrane; Single-pass type I membrane protein. Secreted Note=Isoforms that contain the exon coding for a furin-type cleavage site are proteolytically processed, leading to a secreted receptor fragment.
Tissue Location Expressed mainly in brain and placenta. Also expressed in platelets and megakaryocytic cells. Not expressed in the liver.
Research Areas

BACKGROUND

Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor.

REFERENCES

Kim D.-H.,et al.J. Biol. Chem. 271:8373-8380(1996).
Kim D.-H.,et al.J. Biol. Chem. 272:8498-8504(1997).
Korschineck I.,et al.J. Biol. Chem. 276:13192-13197(2001).
Gregory S.G.,et al.Nature 441:315-321(2006).
Clatworthy A.E.,et al.Neuroscience 90:903-911(1999).

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