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NCKX2 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | Q9UI40 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 74 KDa |
| Gene ID | 25769 |
|---|---|
| Other Names | Sodium/potassium/calcium exchanger 2, Na(+)/K(+)/Ca(2+)-exchange protein 2, Retinal cone Na-Ca+K exchanger, Solute carrier family 24 member 2, SLC24A2, NCKX2 |
| Target/Specificity | KLH conjugated synthetic peptide derived from human NCKX2 |
| Dilution | WB~~ 1:1000 |
| Format | 0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | SLC24A2 |
|---|---|
| Synonyms | NCKX2 |
| Function | Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). |
| Cellular Location | Membrane; Multi-pass membrane protein. |
Research Areas
BACKGROUND
Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).
REFERENCES
Prinsen C.F.M.,et al.J. Neurosci. 20:1424-1434(2000).
Humphray S.J.,et al.Nature 429:369-374(2004).
Kinjo T.G.,et al.Biochemistry 42:2485-2491(2003).
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