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NRL Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - NRL Antibody AP51804
    All lanes : Anti-NRL Antibody at 1:1000 dilution Lane 1: 293T whole cell lysates Lane 2: PC-12 whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 26 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P54845
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 29 KDa
Additional info
Gene ID 4901
Other Names Neural retina-specific leucine zipper protein, NRL, NRL, D14S46E
Target/Specificity KLH conjugated synthetic peptide derived from human NRL
Dilution WB~~ 1:1000
Format 0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name NRL
Synonyms D14S46E
Function Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B (PubMed:21981118). Functions also as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3 (PubMed:17335001). Binds in a sequence-specific manner to the rhodopsin promoter (PubMed:17335001).
Cellular Location Cytoplasm. Nucleus
Tissue Location Expressed in the brain and the retina (PubMed:11477108). Expressed strongly in rod and cone cells (at protein level) (PubMed:11477108).
Research Areas

BACKGROUND

Transcription factor which regulates the expression of several rod-specific genes, in cluding RHO and PDE6B (By similarity).

REFERENCES

Swaroop A.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:266-270(1992).
Jackson A.U.,et al.Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases.
Farjo Q.,et al.Genomics 45:395-401(1997).
Li W.B.,et al.Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.

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