|Reactivity||Human, Mouse, Rat|
|Calculated MW||29 KDa|
|Other Names||Neural retina-specific leucine zipper protein, NRL, NRL, D14S46E|
|Target/Specificity||KLH conjugated synthetic peptide derived from human NRL|
|Format||0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%|
|Storage||Store at -20 °C.Stable for 12 months from date of receipt|
|Function||Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B (PubMed:21981118). Functions also as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3 (PubMed:17335001). Binds in a sequence-specific manner to the rhodopsin promoter (PubMed:17335001).|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Expressed in the brain and the retina (PubMed:11477108). Expressed strongly in rod and cone cells (at protein level) (PubMed:11477108).|
Transcription factor which regulates the expression of several rod-specific genes, in cluding RHO and PDE6B (By similarity).
Swaroop A.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:266-270(1992).
Jackson A.U.,et al.Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases.
Farjo Q.,et al.Genomics 45:395-401(1997).
Li W.B.,et al.Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.