|Calculated MW||34 KDa|
|Other Names||Killer cell immunoglobulin-like receptor 2DS5, CD158 antigen-like family member G, MHC class I NK cell receptor, Natural killer-associated transcript 9, NKAT-9, CD158g, KIR2DS5, CD158G, NKAT9|
|Target/Specificity||KLH conjugated synthetic peptide derived from human CD158g|
|Format||0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%|
|Storage||Store at -20 °C.Stable for 12 months from date of receipt|
|Function||Activating natural killer (NK) receptor that recognizes C2 epitopes of HLA-C alleles. Bridging the innate and adaptive immune systems, NK cells express a number of cell surface receptors which either inhibit or stimulate their cytotoxicity (PubMed:28685972, PubMed:18624290, PubMed:18682925). Able to activate NK cells citotoxicity and cytokine production such as IFNG (PubMed:18624290, PubMed:24269691). Receptor functions are attenuated even lost in some alleles, such as KIR2DS5*002 reprensented in this entry (PubMed:28685972).|
|Cellular Location||Cell membrane; Single- pass type I membrane protein; Extracellular side|
|Tissue Location||Expressed on a discrete subset of peripheral blood NK cells.|
Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.
Doehring C.,et al.Immunogenetics 44:227-230(1996).