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ADA2A Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - ADA2A Antibody AP51664
    All lanes : Anti-ADA2A Antibody at 1:1000 dilution Lane 1: MCF-7 whole cell lysates Lane 2: human testis lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 52 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession O75478
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 51 KDa
Additional info
Other Names Transcriptional adapter 2-alpha, Transcriptional adapter 2-like, ADA2-like protein, TADA2A, TADA2L
Target/Specificity KLH conjugated synthetic peptide derived from human ADA2A
Dilution WB~~ 1:1000
Format 0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name TADA2A
Synonyms TADA2L
Function Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double- stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity (PubMed:22644376). May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage (PubMed:22644376).
Cellular Location Nucleus. Chromosome {ECO:0000250|UniProtKB:Q8CHV6}
Tissue Location Expressed in all tissues, but most abundantly in testis EMBL; AF064094; AAC26659.1; -; mRNA EMBL; AK022767; BAG51111.1; -; mRNA EMBL; AC004099; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; AC068400; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; AC068447; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; BC001172; AAH01172.1; -; mRNA EMBL; BC011753; AAH11753.1; -; mRNA EMBL; AF069732; AAC39902.1; -; mRNA CCDS; CCDS11319.1; -. [O75478-1] CCDS; CCDS45656.1; -. [O75478-2] RefSeq; NP_001159577.2; NM_001166105.2 RefSeq; NP_001278847.1; NM_001291918.1 RefSeq; NP_001479.4; NM_001488.4 RefSeq; NP_597683.3; NM_133439.3 UniGene; Hs.500066; - UniGene; Hs.633101; - PDB; 1X41; NMR; -; A=72-116 PDBsum; 1X41; - ProteinModelPortal; O75478; - SMR; O75478; - BioGrid; 112734; 158 ComplexPortal; CPX-1004; PCAF-containing ATAC complex ComplexPortal; CPX-989; PCAF histone acetylase complex ComplexPortal; CPX-997; GCN5-containing ATAC complex CORUM; O75478; - DIP; DIP-28151N; - IntAct; O75478; 52 MINT; O75478; - STRING; 9606.ENSP00000225396; - iPTMnet; O75478; - PhosphoSitePlus; O75478; - BioMuta; TADA2A; - EPD; O75478; - jPOST; O75478; - MaxQB; O75478; - PaxDb; O75478; - PeptideAtlas; O75478; - PRIDE; O75478; - ProteomicsDB; 50040; - ProteomicsDB; 50041; -. [O75478-2] DNASU; 6871; - Ensembl; ENST00000617828; ENSP00000482484; ENSG00000277104. [O75478-1] Ensembl; ENST00000622522; ENSP00000481283; ENSG00000277104. [O75478-1] Ensembl; ENST00000633468; ENSP00000488016; ENSG00000277104. [O75478-1] Ensembl; ENST00000633584; ENSP00000487973; ENSG00000277104. [O75478-2] GeneID; 6871; - KEGG; hsa:6871; - UCSC; uc032ghw.2; human. [O75478-1] CTD; 6871; - DisGeNET; 6871; - GeneCards; TADA2A; - H-InvDB; HIX0013744; - HGNC; HGNC:11531; TADA2A HPA; HPA076497; - MIM; 602276; gene neXtProt; NX_O75478; - PharmGKB; PA36306; - eggNOG; KOG0457; Eukaryota eggNOG; COG5114; LUCA HOGENOM; HOG000068147; - HOVERGEN; HBG060876; - InParanoid; O75478; - KO; K11314; - OrthoDB; 812864at2759; - PhylomeDB; O75478; - TreeFam; TF313975; - Reactome; R-HSA-3214847; HATs acetylate histones ChiTaRS; TADA2A; human EvolutionaryTrace; O75478; - GeneWiki; TADA2L; - GenomeRNAi; 6871; - PRO; PR:O75478; - Proteomes; UP000005640; Chromosome 17 GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell GO; GO:0005634; C:nucleus; IBA:GO_Central GO; GO:0000125; C:PCAF complex; IDA:UniProtKB GO; GO:0070461; C:SAGA-type complex; IBA:GO_Central GO; GO:0003682; F:chromatin binding; IBA:GO_Central GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central GO; GO:0043966; P:histone H3 acetylation; IDA:UniProtKB GO; GO:0035066; P:positive regulation of histone acetylation; IBA:GO_Central GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central CDD; cd00167; SANT; 1 InterPro; IPR016827; Ada2/TADA2 InterPro; IPR009057; Homeobox-like_sf InterPro; IPR001005; SANT/Myb InterPro; IPR017884; SANT_dom InterPro; IPR007526; SWIRM Pfam; PF00249; Myb_DNA-binding; 1 Pfam; PF04433; SWIRM; 1 PIRSF; PIRSF025024; Transcriptional_adaptor_2; 1 SMART; SM00717; SANT; 1 SUPFAM; SSF46689; SSF46689; 2 PROSITE; PS51293; SANT; 1 PROSITE; PS50934; SWIRM; 1 1: Evidence at protein level; 3D-structure; Alternative splicing; Chromosome; Complete proteome; DNA-binding; Isopeptide bond; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation; Ubl conjugation CHAIN 1 443 Transcriptional adapter 2-alpha /FTId=PRO_0000197083 DOMAIN 70 122 SANT. {ECO:0000255|PROSITE- ProRule:PRU00624} DOMAIN 356 443 SWIRM. {ECO:0000255|PROSITE- ProRule:PRU00247} DNA_BIND 426 435 COMPBIAS 17 45 Cys-rich MOD_RES 6 6 Phosphoserine; in variant Ser-6 CROSSLNK 132 132 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) CROSSLNK 138 138 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) VAR_SEQ 275 305 LEFELRREIKRLQEYRTAGITNFCSARTYDH -> CRWFLS LEQYLCVYIYINRRDNGVFYVKFYK (in isoform 2) /FTId=VSP_040347 VAR_SEQ 306 443 Missing (in isoform 2) /FTId=VSP_040348 VARIANT 6 6 P -> S (in dbSNP:rs7211875) {ECO:0000244|PubMed:23186163, ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:8552087, ECO:0000269|Ref.2} /FTId=VAR_047466 VARIANT 115 115 M -> V (in dbSNP:rs1054865) /FTId=VAR_047467 VARIANT 351 351 I -> M (in dbSNP:rs2522969) /FTId=VAR_047468 CONFLICT 117 117 H -> Y (in Ref. 5; AAH01172) CONFLICT 153 153 P -> L (in Ref. 6; AAC39902) CONFLICT 185 185 W -> R (in Ref. 2; AAC26659) CONFLICT 304 304 D -> N (in Ref. 2; AAC26659) CONFLICT 342 342 D -> G (in Ref. 2; AAC26659) STRAND 73 75 {ECO:0000244|PDB:1X41} HELIX 77 89 {ECO:0000244|PDB:1X41} HELIX 95 102 {ECO:0000244|PDB:1X41} HELIX 107 117 {ECO:0000244|PDB:1X41} SEQUENCE 443 AA; 51506 MW; A4E1D87B1B3F6BA5 CRC64; MDRLGPFSND PSDKPPCRGC SSYLMEPYIK CAECGPPPFF LCLQCFTRGF EYKKHQSDHT YEIMTSDFPV LDPSWTAQEE MALLEAVMDC GFGNWQDVAN QMCTKTKEEC EKHYMKHFIN NPLFASTLLN LKQAEEAKTA DTAIPFHSTD DPPRPTFDSL LSRDMAGYMP ARADFIEEFD NYAEWDLRDI DFVEDDSDIL HALKMAVVDI YHSRLKERQR RKKIIRDHGL INLRKFQLME RRYPKEVQDL YETMRRFARI VGPVEHDKFI ESHALEFELR REIKRLQEYR TAGITNFCSA RTYDHLKKTR EEERLKRTML SEVLQYIQDS SACQQWLRRQ ADIDSGLSPS IPMASNSGRR SAPPLNLTGL PGTEKLNEKE KELCQMVRLV PGAYLEYKSA LLNECNKQGG LRLAQARALI KIDVNKTRKI YDFLIREGYI TKG
Research Areas

BACKGROUND

Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double- stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling.

REFERENCES

Candau R.,et al.Mol. Cell. Biol. 16:593-602(1996).
Huang X.,et al.Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Ogryzko V.V.,et al.Cell 94:35-44(1998).

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