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USF2 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - USF2 Antibody AP51602
    All lanes : Anti-USF2 Antibody at 1:1000 dilution Lane 1: A431 whole cell lysates Lane 2: Jurkat whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 37 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q15853
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 44 KDa
Additional info
Other Names Upstream stimulatory factor 2, Class B basic helix-loop-helix protein 12, bHLHb12, FOS-interacting protein, FIP, Major late transcription factor 2, Upstream transcription factor 2, USF2, BHLHB12
Target/Specificity KLH conjugated synthetic peptide derived from human USF2
Dilution WB~~ 1:1000
Format 0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name USF2
Synonyms BHLHB12
Function Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.
Cellular Location Nucleus.
Tissue Location Ubiquitous. EMBL; X90824; CAA62339.1; -; mRNA EMBL; X90825; CAA62340.1; -; mRNA EMBL; X90826; CAA62341.1; -; mRNA EMBL; Y07661; CAA68942.1; -; Genomic_DNA EMBL; AY147880; AAN63092.1; -; mRNA EMBL; CR536504; CAG38742.1; -; mRNA EMBL; AD000684; AAB51179.1; -; Genomic_DNA EMBL; BC049821; AAH49821.1; -; mRNA EMBL; S50537; AAB24368.1; -; mRNA EMBL; M77476; -; NOT_ANNOTATED_CDS; mRNA CCDS; CCDS12452.1; -. [Q15853-1] CCDS; CCDS12453.1; -. [Q15853-3] CCDS; CCDS82329.1; -. [Q15853-4] PIR; I54074; I54074 RefSeq; NP_001308079.1; NM_001321150.1. [Q15853-4] RefSeq; NP_003358.1; NM_003367.3. [Q15853-1] RefSeq; NP_997174.1; NM_207291.2. [Q15853-3] UniGene; Hs.454534; - ProteinModelPortal; Q15853; - SMR; Q15853; - BioGrid; 113238; 32 ComplexPortal; CPX-3079; USF1-USF2 upstream stimulatory factor complex ComplexPortal; CPX-3083; USF2 upstream stimulatory factor complex CORUM; Q15853; - IntAct; Q15853; 16 MINT; Q15853; - STRING; 9606.ENSP00000222305; - iPTMnet; Q15853; - PhosphoSitePlus; Q15853; - BioMuta; USF2; - DMDM; 2833271; - EPD; Q15853; - jPOST; Q15853; - MaxQB; Q15853; - PaxDb; Q15853; - PeptideAtlas; Q15853; - PRIDE; Q15853; - ProteomicsDB; 60794; - ProteomicsDB; 60795; -. [Q15853-2] ProteomicsDB; 60796; -. [Q15853-3] Ensembl; ENST00000222305; ENSP00000222305; ENSG00000105698. [Q15853-1] Ensembl; ENST00000343550; ENSP00000340633; ENSG00000105698. [Q15853-3] Ensembl; ENST00000379134; ENSP00000368429; ENSG00000105698. [Q15853-4] Ensembl; ENST00000595068; ENSP00000471099; ENSG00000105698. [Q15853-2] GeneID; 7392; - KEGG; hsa:7392; - UCSC; uc002nyq.2; human. [Q15853-1] CTD; 7392; - DisGeNET; 7392; - EuPathDB; HostDB:ENSG00000105698.15; - GeneCards; USF2; - HGNC; HGNC:12594; USF2 HPA; HPA029764; - HPA; HPA046567; - MIM; 600390; gene neXtProt; NX_Q15853; - OpenTargets; ENSG00000105698; - PharmGKB; PA37224; - eggNOG; ENOG410INSC; Eukaryota eggNOG; ENOG4111DV1; LUCA GeneTree; ENSGT00940000160704; - HOGENOM; HOG000294174; - HOVERGEN; HBG004346; - InParanoid; Q15853; - KO; K09106; - OrthoDB; 1345445at2759; - PhylomeDB; Q15853; - TreeFam; TF323338; - Reactome; R-HSA-9018519; Estrogen-dependent gene expression SignaLink; Q15853; - SIGNOR; Q15853; - ChiTaRS; USF2; human GeneWiki; USF2; - GenomeRNAi; 7392; - PRO; PR:Q15853; - Proteomes; UP000005640; Chromosome 19 Bgee; ENSG00000105698; Expressed in 234 organ(s), highest expression level in frontal cortex ExpressionAtlas; Q15853; baseline and differential Genevisible; Q15853; HS GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA GO; GO:0005654; C:nucleoplasm; IDA:HPA GO; GO:0005634; C:nucleus; IDA:BHF-UCL GO; GO:0043425; F:bHLH transcription factor binding; IPI:BHF-UCL GO; GO:0003700; F:DNA-binding transcription factor activity; TAS:ProtInc GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IMP:BHF-UCL GO; GO:0046982; F:protein heterodimerization activity; IPI:BHF-UCL GO; GO:0042803; F:protein homodimerization activity; IPI:BHF-UCL GO; GO:0043565; F:sequence-specific DNA binding; IDA:BHF-UCL GO; GO:0007595; P:lactation; IEA:Ensembl GO; GO:0019086; P:late viral transcription; IC:BHF-UCL GO; GO:0055088; P:lipid homeostasis; ISS:BHF-UCL GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:BHF-UCL GO; GO:0000432; P:positive regulation of transcription from RNA polymerase II promoter by glucose; IMP:BHF-UCL GO; GO:0000430; P:regulation of transcription from RNA polymerase II promoter by glucose; IC:BHF-UCL GO; GO:0006366; P:transcription by RNA polymerase II; IMP:BHF-UCL CDD; cd00083; HLH; 1 Gene3D; 4.10.280.10; -; 1 InterPro; IPR011598; bHLH_dom InterPro; IPR024097; bHLH_ZIP_TF InterPro; IPR036638; HLH_DNA-bd_sf PANTHER; PTHR12565; PTHR12565; 1 Pfam; PF00010; HLH; 1 SMART; SM00353; HLH; 1 SUPFAM; SSF47459; SSF47459; 1 PROSITE; PS50888; BHLH; 1 1: Evidence at protein level; Alternative splicing; Complete proteome; DNA-binding; Nucleus; Reference proteome; Transcription; Transcription regulation CHAIN 1 346 Upstream stimulatory factor 2 /FTId=PRO_0000127500 DOMAIN 235 290 bHLH. {ECO:0000255|PROSITE- ProRule:PRU00981} REGION 307 328 Leucine-zipper COMPBIAS 11 20 Poly-Ala COMPBIAS 245 248 Poly-Arg VAR_SEQ 76 206 Missing (in isoform USF2c) /FTId=VSP_047804 VAR_SEQ 77 143 Missing (in isoform USF2B) /FTId=VSP_002164 VAR_SEQ 275 282 Missing (in isoform USF2A-delta-H) /FTId=VSP_002165 CONFLICT 46 64 QTAVAITSVQQAAFGDHNI -> GGGTSGGRGSGIQTRVQH V (in Ref. 7). CONFLICT 93 100 GDTAGAVS -> EFHSWRRH (in Ref. 8; M77476) CONFLICT 122 122 A -> V (in Ref. 8; M77476) CONFLICT 308 308 Q -> R (in Ref. 4; CAG38742) SEQUENCE 346 AA; 36955 MW; 78CEFE97AC4C10CF CRC64; MDMLDPGLDP AASATAAAAA SHDKGPEAEE GVELQEGGDG PGAEEQTAVA ITSVQQAAFG DHNIQYQFRT ETNGGQVTYR VVQVTDGQLD GQGDTAGAVS VVSTAAFAGG QQAVTQVGVD GAAQRPGPAA ASVPPGPAAP FPLAVIQNPF SNGGSPAAEA VSGEARFAYF PASSVGDTTA VSVQTTDQSL QAGGQFYVMM TPQDVLQTGT QRTIAPRTHP YSPKIDGTRT PRDERRRAQH NEVERRRRDK INNWIVQLSK IIPDCNADNS KTGASKGGIL SKACDYIREL RQTNQRMQET FKEAERLQMD NELLRQQIEE LKNENALLRA QLQQHNLEMV GEGTRQ
Research Areas

BACKGROUND

Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.

REFERENCES

Viollet B.,et al.J. Biol. Chem. 271:1405-1415(1996).
Groenen P.M.A.,et al.Genomics 38:141-148(1996).
Yan S.,et al.Gene 337:199-206(2004).
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Grimwood J.,et al.Nature 428:529-535(2004).

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