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>   首页   >   产品   >   一抗   >   癌症   >   PGHS-2 Antibody   

PGHS-2 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - PGHS-2 Antibody AP51459
    Anti-PGHS-2 Antibodyat 1:1000 dilution + A549 whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 69 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P35354
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 74 KDa
Additional info
Gene ID 5743
Other Names Prostaglandin G/H synthase 2, Cyclooxygenase-2, COX-2, PHS II, Prostaglandin H2 synthase 2, PGH synthase 2, PGHS-2, Prostaglandin-endoperoxide synthase 2, PTGS2, COX2
Target/Specificity KLH conjugated synthetic peptide derived from human PGHS-2
Dilution WB~~ 1:1000
Format 0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name PTGS2
Synonyms COX2
Function Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.
Cellular Location Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein
Research Areas

BACKGROUND

Critical component of colonic mucosal wound repair (By similarity). Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.

REFERENCES

Jones D.A.,et al.J. Biol. Chem. 268:9049-9054(1993).
Hla T.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:7384-7388(1992).
Kosaka T.,et al.Eur. J. Biochem. 221:889-897(1994).
Appleby S.B.,et al.Biochem. J. 302:723-727(1994).
Sharma S.V.,et al.Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.

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