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Patched Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - Patched Antibody AP51457
    Anti-Patched Antibodyat 1:1000 dilution + MCF-7 whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 161 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q13635
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 160 KDa
Additional info
Gene ID 5727
Other Names Protein patched homolog 1, PTC, PTC1, PTCH1, PTCH
Target/Specificity KLH conjugated synthetic peptide derived from human Patched
Dilution WB~~ 1:1000
Format 0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name PTCH1
Synonyms PTCH
Function Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.
Cellular Location Membrane; Multi-pass membrane protein.
Tissue Location In the adult, expressed in brain, lung, liver, heart, placenta, skeletal muscle, pancreas and kidney. Expressed in tumor cells but not in normal skin
Research Areas

BACKGROUND

Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.

REFERENCES

Johnson R.L.,et al.Science 272:1668-1671(1996).
Hahn H.,et al.J. Biol. Chem. 271:12125-12128(1996).
Humphray S.J.,et al.Nature 429:369-374(2004).
Nagao K.,et al.Genomics 85:462-471(2005).
Shimokawa T.,et al.Oncogene 26:4889-4896(2007).

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