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>   首页   >   产品   >   一抗   >   细胞生物学   >   NEURL2 Antibody   

NEURL2 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - NEURL2 Antibody AP51385
    Anti-NEURL2 Antibody at 1:1000 dilution + human skeletal muscle lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 32 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q9BR09
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 32 KDa
Additional info
Gene ID 140825
Other Names Neuralized-like protein 2, NEURL2, C20orf163
Target/Specificity KLH conjugated synthetic peptide derived from human NEURL2
Dilution WB~~ 1:1000
Format 0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name NEURL2
Synonyms C20orf163
Function Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity).
Cellular Location Cytoplasm.
Tissue Location Expressed specifically in skeletal and cardiac muscles.
Research Areas

BACKGROUND

Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity).

REFERENCES

Ota T.,et al.Nat. Genet. 36:40-45(2004).
Frigimelica E.,et al.Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
Deloukas P.,et al.Nature 414:865-871(2001).
Nastasi T.,et al.Dev. Cell 6:269-282(2004).

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