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>   首页   >   产品   >   一抗   >   心血管   >   MEOX2 Antibody   

MEOX2 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - MEOX2 Antibody AP51341
    All lanes : Anti-MEOX2 Antibody at 1:1000 dilution Lane 1: Hela whole cell lysates Lane 2: NIH/3T3 whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 34 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P50222
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 34 KDa
Additional info
Gene ID 4223
Other Names Homeobox protein MOX-2, Growth arrest-specific homeobox, Mesenchyme homeobox 2, MEOX2, GAX, MOX2
Target/Specificity KLH conjugated synthetic peptide derived from human MEOX2
Dilution WB~~ 1:1000
Format 0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name MEOX2
Synonyms GAX, MOX2
Function Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development (By similarity). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle.
Cellular Location Nucleus. Nucleus speckle {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:19266028}
Tissue Location Embryo and placenta.
Research Areas

BACKGROUND

Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and sclerotomal differentiation. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (By similarity).

REFERENCES

Grigoriou M.,et al.Genomics 26:550-555(1995).
Lepage D.F.,et al.Genomics 24:535-540(1994).
Hillier L.W.,et al.Nature 424:157-164(2003).
Lin J.,et al.Mol. Cell. Biochem. 275:75-84(2005).
Salichs E.,et al.PLoS Genet. 5:E1000397-E1000397(2009).

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