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DBF4 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - DBF4 Antibody AP51156
    All lanes : Anti-DBF4 Antibody at 1:1000 dilution Lane 1: NIH/3T3 whole cell lysates Lane 2: HepG2 whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 77 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q9UBU7
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 77 KDa
Additional info
Gene ID 10926
Other Names Protein DBF4 homolog A, Activator of S phase kinase, Chiffon homolog A, DBF4-type zinc finger-containing protein 1, DBF4, ASK, DBF4A, ZDBF1
Target/Specificity KLH conjugated synthetic peptide derived from human DBF4
Dilution WB~~ 1:1000
Format 0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name DBF4
Synonyms ASK, DBF4A, ZDBF1
Function Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle.
Cellular Location Nucleus.
Tissue Location Highly expressed in testis and thymus. Expressed also in most cancer cells lines
Research Areas

BACKGROUND

Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle.

REFERENCES

Kumagai H.,et al.Mol. Cell. Biol. 19:5083-5095(1999).
Jiang W.,et al.EMBO J. 18:5703-5713(1999).
Hollingsworth R.,et al.Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 424:157-164(2003).

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