- 文献引用 : 1
|Calculated MW||25 KDa|
|Other Names||Caspase-1, CASP-1, Interleukin-1 beta convertase, IL-1BC, Interleukin-1 beta-converting enzyme, ICE, IL-1 beta-converting enzyme, p45, Caspase-1 subunit p20, Caspase-1 subunit p10, CASP1, IL1BC, IL1BCE|
|Target/Specificity||KLH conjugated synthetic peptide derived from human Caspase 1|
|Format||0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%|
|Storage||Store at -20 °C.Stable for 12 months from date of receipt|
|Function||Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive (PubMed:28314590).|
|Tissue Location||Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.|
Author : He B1,2,3,Shi Y2,4,Liang Y1,2,3,Yang A1,2,3,Fan Z1,2,3,Yuan L5,Zou X5,Chang X5,Zhang H1,2,3,Wang X1,2,3,Dai W1,2,3,Wang Y1,2,3,Zhang Q6,7,8.
Nat Commun. 2018 Jun 19;9(1):2393. doi: 10.1038/s41467-018-04700-z.
Provided below are standard protocols that you may find useful for product applications.
Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.
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