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Caspase 1 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - Caspase 1 Antibody AP51035
    All lanes : Anti-Caspase 1 Antibody at 1:1000 dilution Lane 1: H.spleen tissue lysates Lane 2: H.lung tissue lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 45 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P29466
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 25 KDa
Additional info
Gene ID 834
Other Names Caspase-1, CASP-1, Interleukin-1 beta convertase, IL-1BC, Interleukin-1 beta-converting enzyme, ICE, IL-1 beta-converting enzyme, p45, Caspase-1 subunit p20, Caspase-1 subunit p10, CASP1, IL1BC, IL1BCE
Target/Specificity KLH conjugated synthetic peptide derived from human Caspase 1
Dilution WB~~ 1:1000
Format 0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name CASP1
Synonyms IL1BC, IL1BCE
Function Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.
Cellular Location Cytoplasm.
Tissue Location Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.
Research Areas
Single-walled carbon-nanohorns improve biocompatibility over nanotubes by triggering less protein-initiated pyroptosis and apoptosis in macrophages.
Author : He B1,2,3,Shi Y2,4,Liang Y1,2,3,Yang A1,2,3,Fan Z1,2,3,Yuan L5,Zou X5,Chang X5,Zhang H1,2,3,Wang X1,2,3,Dai W1,2,3,Wang Y1,2,3,Zhang Q6,7,8.
Nat Commun. 2018 Jun 19;9(1):2393. doi: 10.1038/s41467-018-04700-z.
29921862

BACKGROUND

Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.

REFERENCES

Thornberry N.A.,et al.Nature 356:768-774(1992).
Cerretti D.P.,et al.Science 256:97-100(1992).
Alnemri E.S.,et al.J. Biol. Chem. 270:4312-4317(1995).
Totoki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Taylor T.D.,et al.Nature 440:497-500(2006).

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