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NAP1 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - NAP1 Antibody AP51007
    Anti-NAP1 Antibody at 1:1000 dilution + HepG2 whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 45 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q9H6S1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 45 KDa
Additional info
Gene ID 64343
Other Names 5-azacytidine-induced protein 2, NF-kappa-B-activating kinase-associated protein 1, Nak-associated protein 1, TILP, AZI2, NAP1, TBKBP2
Target/Specificity KLH conjugated synthetic peptide derived from human NAP1
Dilution WB~~ 1:1000
Format 0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name AZI2
Synonyms NAP1, TBKBP2
Function Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine- protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1.
Cellular Location Cytoplasm.
Tissue Location Widely expressed. Abundant expression seen in the pancreas and testis.
Research Areas

BACKGROUND

Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine- protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1.

REFERENCES

Fujita F.,et al.Mol. Cell. Biol. 23:7780-7793(2003).
Inohara N.,et al.Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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