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>   首页   >   产品   >   一抗   >   细胞生物学   >   Ataxin 2 Antibody   

Ataxin 2 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - Ataxin 2 Antibody AP51006
    Anti-Ataxin 2 Antibodyat 1:2000 dilution + human brain lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 140 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q99700
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 140 KDa
Additional info
Gene ID 6311
Other Names Ataxin-2, Spinocerebellar ataxia type 2 protein, Trinucleotide repeat-containing gene 13 protein, ATXN2, ATX2, SCA2, TNRC13
Target/Specificity KLH conjugated synthetic peptide derived from human Ataxin 2
Dilution WB~~ 1:2000
Format 0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name ATXN2
Synonyms ATX2, SCA2, TNRC13
Function Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane.
Cellular Location Cytoplasm.
Tissue Location Expressed in the brain, heart, liver, skeletal muscle, pancreas and placenta. Isoform 1 is predominant in the brain and spinal cord. Isoform 4 is more abundant in the cerebellum. In the brain, broadly expressed in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus
Research Areas

BACKGROUND

Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane.

REFERENCES

Pulst S.-M.,et al.Nat. Genet. 14:269-276(1996).
Sanpei K.,et al.Nat. Genet. 14:277-284(1996).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
Imbert G.,et al.Nat. Genet. 14:285-291(1996).

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