|Calculated MW||46 KDa|
|Other Names||Arrestin domain-containing protein 1, ARRDC1|
|Target/Specificity||KLH conjugated synthetic peptide derived from human ARRDC1|
|Format||0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%|
|Storage||Store at -20 °C.Stable for 12 months from date of receipt|
|Function||Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (PubMed:23886940, PubMed:27462458). Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles (PubMed:27462458). More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles (PubMed:22315426). By participating to the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway (PubMed:23886940).|
|Cellular Location||Cell membrane. Note=Also found in extracellular vesicles different from exosomes.|
Humphray S.J.,et al.Nature 429:369-374(2004).