|Reactivity||Human, Mouse, Rat|
|Calculated MW||47 KDa|
|Other Names||Actin-related protein 3, Actin-like protein 3, ACTR3, ARP3|
|Target/Specificity||KLH conjugated synthetic peptide derived from human ARP3|
|Format||0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%|
|Storage||Store at -20 °C.Stable for 12 months from date of receipt|
|Function||ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double- strand breaks (DSBs) (PubMed:29925947). Plays a role in ciliogenesis (PubMed:20393563).|
|Cellular Location||Cytoplasm, cytoskeleton. Cell projection. Nucleus. Note=In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes) (PubMed:19109554)|
Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis.
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Szelei J.,et al.Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.