|Reactivity||Human, Mouse, Rat|
|Calculated MW||110 KDa|
|Other Names||ATP-binding cassette sub-family G member 1, ATP-binding cassette transporter 8, White protein homolog, ABCG1, ABC8, WHT1|
|Target/Specificity||KLH conjugated synthetic peptide derived from human ABCG1|
|Format||0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%|
|Storage||Store at -20 °C.Stable for 12 months from date of receipt|
|Function||Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages.|
|Cellular Location||Mitochondrion. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes|
|Tissue Location||Expressed in several tissues. Expressed in macrophages; expression is increased in macrophages from patients with Tangier disease.|
Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages.
Chen H.M.,et al.Am. J. Hum. Genet. 59:66-75(1996).
Berry A.,et al.Genomics 68:22-29(2000).
Porsch-Oezcueruemez M.,et al.J. Biol. Chem. 276:12427-12433(2001).
Lorkowski S.,et al.Biochem. Biophys. Res. Commun. 280:121-131(2001).
Kennedy M.A.,et al.J. Biol. Chem. 276:39438-39447(2001).