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CISH Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - CISH Antibody AP50938
    Western blot analysis of lysates from Hela cell line,human liver,human kidney tissue lysate (from left to right), using CISH Antibody(AP50938). AP50938 was diluted at 1:500 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.Lysates at 20ug per lane.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q9NSE2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 29,31 KDa
Additional info
Gene ID 1154
Other Names Cytokine-inducible SH2-containing protein, CIS, CIS-1, Protein G18, Suppressor of cytokine signaling, SOCS, CISH, G18
Dilution WB~~ 1:500
Format Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 53% glycerol
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name CISH
Synonyms G18
Function SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate- recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
Tissue Location Expressed in various epithelial tissues. Abundantly expressed in liver and kidney, and to a lesser extent in lung. The tissue distribution of isoforms 1 and 1B is distinct
Research Areas

BACKGROUND

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate- recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).

REFERENCES

Uchida K.,et al.Cytogenet. Cell Genet. 78:209-212(1997).
Jiang C.,et al.DNA Seq. 11:149-154(2000).
Wei M.-H.,et al.Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
Yousefi S.,et al.Biochem. Biophys. Res. Commun. 277:401-409(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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