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MED23 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - MED23 Antibody AP50842
    Western blot analysis of lysate from HeLa cell line,using MED23 Antibody, was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.
  • 3 - MED23 Antibody AP50842
    Immunofluorescence analysis of A549 cells, using MED23 antibody.
  • 2 - MED23 Antibody AP50842
    Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using MED23 antibody.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IF, IHC
Primary Accession Q9ULK4
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality polyclonal
Calculated MW 156,101,54 KDa
Additional info
Gene ID 9439
Other Names Mediator of RNA polymerase II transcription subunit 23, Activator-recruited cofactor 130 kDa component, ARC130, Cofactor required for Sp1 transcriptional activation subunit 3, CRSP complex subunit 3, Mediator complex subunit 23, Protein sur-2 homolog, hSur-2, Transcriptional coactivator CRSP130, Vitamin D3 receptor-interacting protein complex 130 kDa component, DRIP130, MED23, ARC130, CRSP3, DRIP130, KIAA1216, SUR2
Dilution WB~~ 1:1000
IF~~1:100
IHC~~1:50~100
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name MED23
Synonyms ARC130, CRSP3, DRIP130, KIAA1216, SUR2
Function Required for transcriptional activation subsequent to the assembly of the preinitiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling.
Cellular Location Nucleus.
Research Areas

BACKGROUND

Required for transcriptional activation subsequent to the assembly of the preinitiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling.

REFERENCES

Rachez C.,et al.Nature 398:824-828(1999).
Boyer T.G.,et al.Nature 399:276-279(1999).
Ryu S.,et al.Nature 397:446-450(1999).
Kivil A.,et al.Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
Nagase T.,et al.DNA Res. 6:337-345(1999).

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