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FOXD3 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - FOXD3 Antibody AP50841
    Western blot analysis of lysate from Ramos cell line,using FOXD3 Antibody, was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.
  • 2 - FOXD3 Antibody AP50841
    Immunohistochemistry analysis of paraffin-embedded human heart tissue using FOXD3 antibody.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC
Primary Accession Q9UJU5
Reactivity Human, Mouse
Host Rabbit
Clonality polyclonal
Calculated MW 48 KDa
Additional info
Gene ID 27022
Other Names Forkhead box protein D3, HNF3/FH transcription factor genesis, FOXD3, HFH2
Dilution WB~~ 1:1000
IHC~~1:50~100
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name FOXD3
Synonyms HFH2
Function Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis.
Cellular Location Nucleus.
Tissue Location Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined
Research Areas

BACKGROUND

Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis.

REFERENCES

Ramsey H.C.,et al.Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).
Hromas R.,et al.Blood 81:2854-2859(1993).
Guo Y.,et al.Proc. Natl. Acad. Sci. U.S.A. 99:3663-3667(2002).
Alkhateeb A.,et al.J. Invest. Dermatol. 125:388-391(2005).

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