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SCN4B Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - SCN4B Antibody AP50819
    Western blot analysis of lysate from human skeletal muscle tissue lysate,using SCN4B Antibody. This antibody was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q8IWT1
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality polyclonal
Calculated MW 25,13,10 KDa
Additional info
Gene ID 6330
Other Names Sodium channel subunit beta-4, SCN4B
Dilution WB~~ 1:1000
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name SCN4B
Function Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the suceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Expressed in the atrium.
Research Areas

BACKGROUND

Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation (By similarity).

REFERENCES

Yu F.H.,et al.J. Neurosci. 23:7577-7585(2003).
Taylor T.D.,et al.Nature 440:497-500(2006).
Medeiros-Domingo A.,et al.Circulation 116:134-142(2007).

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