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CBLN3 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - CBLN3 Antibody AP50784
    Western blot analysis of lysates from Raji,Daudi cell line (from left to right),using CBLN3 Antibody(AP50784). AP50784 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysates at 35ug per lane.
  • 2 - CBLN3 Antibody AP50784
    Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using CBLN3 antibody.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC
Primary Accession Q6UW01
Reactivity Human, Mouse
Host Rabbit
Clonality polyclonal
Calculated MW 22 KDa
Additional info
Other Names Cerebellin-3, CBLN3
Dilution WB~~ 1:1000
IHC~~1:50-100
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name CBLN3
Function May be involved in synaptic functions in the CNS.
Cellular Location Endoplasmic reticulum. Golgi apparatus, cis-Golgi network. Secreted. Cell junction, synapse. Note=In the absence of CBLN1, remains in the endoplasmic reticulum/cis-Golgi apparatus. Partial secretion depends on an association with CBLN1 and maybe CBLN4, but not on CBLN2 (By similarity). EMBL; AY359070; AAQ89429.1; -; mRNA CCDS; CCDS32057.1; - RefSeq; NP_001034860.1; NM_001039771.2 UniGene; Hs.207603; - ProteinModelPortal; Q6UW01; - SMR; Q6UW01; - STRING; 9606.ENSP00000267406; - iPTMnet; Q6UW01; - PhosphoSitePlus; Q6UW01; - BioMuta; CBLN3; - DMDM; 52782722; - PaxDb; Q6UW01; - PeptideAtlas; Q6UW01; - PRIDE; Q6UW01; - ProteomicsDB; 67440; - Ensembl; ENST00000267406; ENSP00000267406; ENSG00000139899 GeneID; 643866; - KEGG; hsa:643866; - UCSC; uc001wpg.5; human CTD; 643866; - EuPathDB; HostDB:ENSG00000139899.10; - GeneCards; CBLN3; - HGNC; HGNC:20146; CBLN3 HPA; HPA041266; - MIM; 612978; gene neXtProt; NX_Q6UW01; - OpenTargets; ENSG00000139899; - PharmGKB; PA134885212; - eggNOG; ENOG410J973; Eukaryota eggNOG; ENOG4111BES; LUCA GeneTree; ENSGT00940000162110; - HOGENOM; HOG000085657; - HOVERGEN; HBG108329; - InParanoid; Q6UW01; - OMA; WAQEGTE; - OrthoDB; 771251at2759; - PhylomeDB; Q6UW01; - TreeFam; TF329591; - GenomeRNAi; 643866; - PRO; PR:Q6UW01; - Proteomes; UP000005640; Chromosome 14 Bgee; ENSG00000139899; Expressed in 115 organ(s), highest expression level in cerebellar hemisphere ExpressionAtlas; Q6UW01; baseline and differential Genevisible; Q6UW01; HS GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell GO; GO:0005615; C:extracellular space; IEA:Ensembl GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell Gene3D; 2.60.120.40; -; 1 InterPro; IPR001073; C1q_dom InterPro; IPR008983; Tumour_necrosis_fac-like_dom Pfam; PF00386; C1q; 1 PRINTS; PR00007; COMPLEMNTC1Q SMART; SM00110; C1Q; 1 SUPFAM; SSF49842; SSF49842; 1 PROSITE; PS50871; C1Q; 1 1: Evidence at protein level; Cell junction; Complete proteome; Direct protein sequencing; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Golgi apparatus; Reference proteome; Secreted; Signal; Synapse SIGNAL 1 32 CHAIN 33 205 Cerebellin-3 /FTId=PRO_0000003554 DOMAIN 67 205 C1q. {ECO:0000255|PROSITE- ProRule:PRU00368} REGION 72 205 Necessary for interaction with CBLN3, and homotrimerization. CARBOHYD 90 90 N-linked (GlcNAc...) asparagine DISULFID 45 45 Interchain. DISULFID 49 49 Interchain. SEQUENCE 205 AA; 21521 MW; 500991AFBB834946 CRC64; MLGAKPHWLP GPLHSPGLPL VLVLLALGAG WAQEGSEPVL LEGECLVVCE PGRAAAGGPG GAALGEAPPG RVAFAAVRSH HHEPAGETGN GTSGAIYFDQ VLVNEGGGFD RASGSFVAPV RGVYSFRFHV VKVYNRQTVQ VSLMLNTWPV ISAFANDPDV TREAATSSVL LPLDPGDRVS LRLRRGNLLG GWKYSSFSGF LIFPL
Research Areas

BACKGROUND

May be involved in synaptic functions in the CNS (By similarity).

REFERENCES

Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Zhang Z.,et al.Protein Sci. 13:2819-2824(2004).

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