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MBTPS1 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - MBTPS1 Antibody AP50769
    Western blot analysis of lysate from U-87 MG cell line,using MBTPS1 Antibody(AP50769). AP50769 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q14703
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality polyclonal
Calculated MW 118 KDa
Additional info
Gene ID 8720
Other Names Membrane-bound transcription factor site-1 protease, Endopeptidase S1P, Subtilisin/kexin-isozyme 1, SKI-1, MBTPS1, KIAA0091, S1P, SKI1
Dilution WB~~ 1:1000
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name MBTPS1
Synonyms KIAA0091, S1P, SKI1
Function Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg- Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes.
Cellular Location Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note=May sort to other organelles, including lysosomal and/or endosomal compartments
Tissue Location Widely expressed.
Research Areas

BACKGROUND

Catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His- Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu.

REFERENCES

Nakajima T.,et al.J. Hum. Genet. 45:212-217(2000).
Nagase T.,et al.DNA Res. 2:37-43(1995).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Toure B.B.,et al.J. Biol. Chem. 275:2349-2358(2000).
Seidah N.G.,et al.Proc. Natl. Acad. Sci. U.S.A. 96:1321-1326(1999).

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