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PTRF Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - PTRF Antibody AP50762
    Western blot analysis of lysate from Hela cell line,using PTRF Antibody(AP50762). AP50762 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q6NZI2
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality polyclonal
Calculated MW 43,33,23 KDa
Additional info
Gene ID 284119
Other Names Polymerase I and transcript release factor, Cavin-1, PTRF {ECO:0000312|EMBL:AAH661231}
Dilution WB~~ 1:1000
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name PTRF {ECO:0000312|EMBL:AAH66123.1}
Function Plays an important role in caveolae formation and organization. Required for the sequestration of mobile caveolin into immobile caveolae. Termination of transcription by RNA polymerase I involves pausing of transcription by TTF1, and the dissociation of the transcription complex, releasing pre-rRNA and RNA polymerase I from the template. PTRF is required for dissociation of the ternary transcription complex.
Cellular Location Membrane, caveola. Cell membrane Microsome. Endoplasmic reticulum. Cytoplasm, cytosol. Mitochondrion. Nucleus Note=Found at the surface of the caveolae. Also found in the plasma membrane, microsomal and cytosolic fractions and at a low level in the mitochondrial and nuclear fractions. Translocates to the cytoplasm from the caveolae upon insulin stimulation. CAV1 is necessary to recruit it to the cell membrane (By similarity). Co- localizes with CAV1 in lipid rafts in adipocytes.
Research Areas

BACKGROUND

Plays an important role in caveolae formation and organization. Required for the sequestration of mobile caveolin into immobile caveolae. Termination of transcription by RNA polymerase I involves pausing of transcription by TTF1, and the dissociation of the transcription complex, releasing pre-rRNA and RNA polymerase I from the template. PTRF is required for dissociation of the ternary transcription complex.

REFERENCES

Wang Y.-G.,et al.Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Jansa P.,et al.EMBO J. 17:2855-2864(1998).
Aboulaich N.,et al.Biochem. J. 383:237-248(2004).

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