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SP3/4 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - SP3/4 Antibody AP50751
    Western blot analysis of lysates from HeLa,Daudi cell line (from left to right),using SP3/4 Antibody(AP50751). AP50751 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysates at 35ug per lane.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q02447
Other Accession Q02446
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality polyclonal
Calculated MW 82,81,54,52,75,77(R&D 100KD) KDa
Additional info
Gene ID 6670
Other Names Transcription factor Sp3, SPR-2, SP3
Dilution WB~~1:1000
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name SP3
Function Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone- induction and house-keeping.
Cellular Location Nucleus. Nucleus, PML body. Note=Localizes to the nuclear periphery and in nuclear dots when sumoylated. Some localization in PML nuclear bodies
Tissue Location Ubiquitously expressed.
Research Areas

BACKGROUND

Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone- induction and house-keeping.

REFERENCES

Hernandez E.M.,et al.J. Biochem. Mol. Biol. 35:273-282(2002).
Moran K.M.,et al.Gene 341:235-247(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Oleksiak M.F.,et al.Mol. Biol. Evol. 19:2026-2029(2002).
Meyer-Grahle U.,et al.Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.

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