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MtSSB Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - MtSSB Antibody AP50738
    Western blot analysis of lysates from 293,UT-7 cell line (from left to right),using MtSSB Antibody(AP50738). AP50738 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysates at 35ug per lane.
  • 3 - MtSSB Antibody AP50738
    Immunofluorescence analysis of A549 cells, using MtSSB antibody.
  • 2 - MtSSB Antibody AP50738
    Immunohistochemistry analysis of paraffin-embedded human pancreas tissue using MtSSB antibody.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IF, IHC
Primary Accession Q04837
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality polyclonal
Calculated MW 17 KDa
Additional info
Other Names Single-stranded DNA-binding protein, mitochondrial, Mt-SSB, MtSSB, PWP1-interacting protein 17, SSBP1, SSBP
Dilution WB~~1:1000
IF~~1:100
IHC~~1:50-100
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name SSBP1
Synonyms SSBP
Function This protein binds preferentially and cooperatively to ss-DNA. Probably involved in mitochondrial DNA replication. Associates with mitochondrial DNA.
Cellular Location Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid EMBL; M94556; AAA36332.1; -; mRNA EMBL; AF277319; AAK69112.1; -; mRNA EMBL; BC000895; AAH00895.1; -; mRNA CCDS; CCDS5866.1; - PIR; JN0568; JN0568 RefSeq; NP_001243439.1; NM_001256510.1 RefSeq; NP_001243440.1; NM_001256511.1 RefSeq; NP_001243441.1; NM_001256512.1 RefSeq; NP_001243442.1; NM_001256513.1 RefSeq; NP_003134.1; NM_003143.2 UniGene; Hs.490394; - UniGene; Hs.740496; - PDB; 1S3O; X-ray; 2.47 A; A/B=17-148 PDB; 2DUD; X-ray; 2.70 A; A/B=16-148 PDB; 3ULL; X-ray; 2.40 A; A/B=17-148 PDBsum; 1S3O; - PDBsum; 2DUD; - PDBsum; 3ULL; - ProteinModelPortal; Q04837; - SMR; Q04837; - BioGrid; 112620; 132 IntAct; Q04837; 53 MINT; Q04837; - STRING; 9606.ENSP00000265304; - iPTMnet; Q04837; - PhosphoSitePlus; Q04837; - BioMuta; SSBP1; - UCD-2DPAGE; Q04837; - EPD; Q04837; - jPOST; Q04837; - MaxQB; Q04837; - PaxDb; Q04837; - PeptideAtlas; Q04837; - PRIDE; Q04837; - ProteomicsDB; 58286; - TopDownProteomics; Q04837; - DNASU; 6742; - Ensembl; ENST00000265304; ENSP00000265304; ENSG00000106028 Ensembl; ENST00000465582; ENSP00000420485; ENSG00000106028 Ensembl; ENST00000481508; ENSP00000419665; ENSG00000106028 Ensembl; ENST00000484178; ENSP00000419388; ENSG00000106028 Ensembl; ENST00000498107; ENSP00000419541; ENSG00000106028 Ensembl; ENST00000570667; ENSP00000460028; ENSG00000262771 Ensembl; ENST00000571430; ENSP00000459367; ENSG00000262771 Ensembl; ENST00000574199; ENSP00000461884; ENSG00000262771 Ensembl; ENST00000575059; ENSP00000458815; ENSG00000262771 Ensembl; ENST00000576834; ENSP00000459208; ENSG00000262771 Ensembl; ENST00000612337; ENSP00000480488; ENSG00000106028 GeneID; 6742; - KEGG; hsa:6742; - UCSC; uc003vwo.3; human CTD; 6742; - DisGeNET; 6742; - EuPathDB; HostDB:ENSG00000106028.10; - GeneCards; SSBP1; - HGNC; HGNC:11317; SSBP1 HPA; HPA002866; - MalaCards; SSBP1; - MIM; 600439; gene neXtProt; NX_Q04837; - OpenTargets; ENSG00000106028; - Orphanet; 90635; Autosomal dominant non-syndromic sensorineural deafness type DFNA PharmGKB; PA36141; - eggNOG; KOG1653; Eukaryota eggNOG; COG0629; LUCA GeneTree; ENSGT00390000002796; - HOVERGEN; HBG001181; - InParanoid; Q04837; - KO; K03111; - OMA; NCIGRFP; - OrthoDB; 1304218at2759; - PhylomeDB; Q04837; - TreeFam; TF314629; - Reactome; R-HSA-2151201; Transcriptional activation of mitochondrial biogenesis ChiTaRS; SSBP1; human EvolutionaryTrace; Q04837; - GeneWiki; SSBP1; - GenomeRNAi; 6742; - PRO; PR:Q04837; - Proteomes; UP000005640; Chromosome 7 Bgee; ENSG00000106028; Expressed in 236 organ(s), highest expression level in material anatomical entity ExpressionAtlas; Q04837; baseline and differential Genevisible; Q04837; HS GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB GO; GO:0005759; C:mitochondrial matrix; TAS:Reactome GO; GO:0042645; C:mitochondrial nucleoid; IDA:BHF-UCL GO; GO:0005739; C:mitochondrion; IDA:HPA GO; GO:0009295; C:nucleoid; IBA:GO_Central GO; GO:0005634; C:nucleus; HDA:UniProtKB GO; GO:0003682; F:chromatin binding; IDA:UniProtKB GO; GO:0003723; F:RNA binding; HDA:UniProtKB GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central GO; GO:0006264; P:mitochondrial DNA replication; IBA:GO_Central GO; GO:0070584; P:mitochondrion morphogenesis; IEA:Ensembl GO; GO:0007005; P:mitochondrion organization; TAS:Reactome GO; GO:0051096; P:positive regulation of helicase activity; IDA:UniProtKB CDD; cd04496; SSB_OBF; 1 HAMAP; MF_00984; SSB; 1 InterPro; IPR012340; NA-bd_OB-fold InterPro; IPR000424; Primosome_PriB/ssb InterPro; IPR011344; ssDNA-bd PANTHER; PTHR10302; PTHR10302; 1 PANTHER; PTHR10302:SF0; PTHR10302:SF0; 1 Pfam; PF00436; SSB; 1 SUPFAM; SSF50249; SSF50249; 1 TIGRFAMs; TIGR00621; ssb; 1 PROSITE; PS50935; SSB; 1 1: Evidence at protein level; 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; DNA replication; DNA-binding; Mitochondrion; Mitochondrion nucleoid; Phosphoprotein; Reference proteome; Transit peptide TRANSIT 1 16 Mitochondrion CHAIN 17 148 Single-stranded DNA-binding protein, mitochondrial /FTId=PRO_0000033263 DOMAIN 30 141 SSB MOD_RES 67 67 Phosphoserine {ECO:0000250|UniProtKB:Q9CYR0} MOD_RES 79 79 Phosphoserine MOD_RES 113 113 N6-acetyllysine MOD_RES 122 122 N6-succinyllysine {ECO:0000250|UniProtKB:Q9CYR0} STRAND 30 39 {ECO:0000244|PDB:3ULL} STRAND 44 46 {ECO:0000244|PDB:3ULL} STRAND 48 51 {ECO:0000244|PDB:1S3O} STRAND 54 65 {ECO:0000244|PDB:3ULL} STRAND 79 89 {ECO:0000244|PDB:3ULL} HELIX 94 101 {ECO:0000244|PDB:3ULL} STRAND 107 115 {ECO:0000244|PDB:3ULL} STRAND 119 126 {ECO:0000244|PDB:3ULL} STRAND 130 138 {ECO:0000244|PDB:3ULL} SEQUENCE 148 AA; 17260 MW; 98EE9E396D5636C2 CRC64; MFRRPVLQVL RQFVRHESET TTSLVLERSL NRVHLLGRVG QDPVLRQVEG KNPVTIFSLA TNEMWRSGDS EVYQLGDVSQ KTTWHRISVF RPGLRDVAYQ YVKKGSRIYL EGKIDYGEYM DKNNVRRQAT TIIADNIIFL SDQTKEKE
Research Areas

BACKGROUND

This protein binds preferentially and cooperatively to ss-DNA. Probably involved in mitochondrial DNA replication. Associates with mitochondrial DNA.

REFERENCES

Tiranti V.,et al.Gene 126:219-225(1993).
Honore B.,et al.Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
Xu G.,et al.Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2009).
Matsuoka S.,et al.Science 316:1160-1166(2007).
Bogenhagen D.F.,et al.J. Biol. Chem. 283:3665-3675(2008).

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