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>   首页   >   产品   >   一抗   >   信号转导   >   JM4 Antibody   

JM4 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - JM4 Antibody AP50707
    Western blot analysis of lysate from SH-SY5Y cell line,using JM4 Antibody(AP50707). AP50707 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.
  • 1 - JM4 Antibody AP50707
    Western blot analysis of extracts from A549 cells (Lane 2), using JM4 Antibody. The lane on the left is treated with systhesized peptide.
  • 2 - JM4 Antibody AP50707
    Immunohistochemical analysis of paraffin-embedded human brain tissue using JM4 antibody (#AP50707).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC
Primary Accession O60831
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality polyclonal
Calculated MW 19 KDa
Additional info
Gene ID 11230
Other Names PRA1 family protein 2, PRAF2
Dilution WB~~1:1000
IHC~~1:50-100
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name PRAF2
Function May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptic role in cerulenin-induced neuroblastoma apoptosis.
Cellular Location Endosome membrane; Multi-pass membrane protein
Tissue Location Strong expression in the brain, small intestine, lung, spleen, and pancreas as well as in tumor tissues of the breast, colon, lung and ovary, with a weaker expression in normal tissues of the same patient. High expression in neuroblastic tumors. Strongly expressed in Purkinje cells and more moderately in cells of the molecular and the granular layers in the cerebellum. Detected in neuronal cells, but not in non- neuronal cells in the cerebral cortex, hippocampus, and lateral ventricles.
Research Areas

BACKGROUND

May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptic role in cerulenin-induced neuroblastoma apoptosis.

REFERENCES

Strom T.M.,et al.Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Schweneker M.,et al.FEBS Lett. 579:1751-1758(2005).

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