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>   首页   >   产品   >   一抗   >   细胞生物学   >   KIF4A Antibody   

KIF4A Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - KIF4A Antibody AP50702
    Western blot analysis of lysates from 293T,U-251 MG cell line (from left to right),using KIF4A Antibody(AP50702). AP50702 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysates at 35ug per lane.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession O95239
Reactivity Human
Host Rabbit
Clonality polyclonal
Calculated MW 140,128 KDa
Additional info
Gene ID 24137
Other Names Chromosome-associated kinesin KIF4A, Chromokinesin-A, KIF4A, KIF4
Dilution WB~~1:1000
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name KIF4A
Synonyms KIF4
Function Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization.
Cellular Location Nucleus matrix. Cytoplasm, cytoskeleton, spindle. Midbody. Chromosome. Note=Not present in the nucleolus In early mitosis, associated with the mitotic spindle, in anaphase, localized to the spindle midzone and, in telophase and cytokinesis, to the midbody. In late cytokinesis, found in the center of the midbody. Associated with chromosomes at all stages of mitosis
Tissue Location Highly expressed in hematopoietic tissues, fetal liver, spleen, thymus and adult thymus and bone marrow Lower levels are found in heart, testis, kidney, colon and lung
Research Areas

BACKGROUND

Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization.

REFERENCES

Villard L.,et al.Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
Oh S.J.,et al.Biochim. Biophys. Acta 1493:219-224(2000).
Rentsch A.,et al.Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ross M.T.,et al.Nature 434:325-337(2005).

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