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>   首页   >   产品   >   一抗   >   其他   >   NARG1 Antibody   

NARG1 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - NARG1 Antibody AP50688
    Western blot analysis of lysate from 293T cell line,using NARG1 Antibody(AP50688). AP50688 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q9BXJ9
Reactivity Human, Mouse
Host Rabbit
Clonality polyclonal
Calculated MW 101,62 KDa
Additional info
Gene ID 80155
Other Names N-alpha-acetyltransferase 15, NatA auxiliary subunit, Gastric cancer antigen Ga19, N-terminal acetyltransferase, NMDA receptor-regulated protein 1, Protein tubedown-1, Tbdn100, NAA15, GA19, NARG1, NATH, TBDN100
Dilution WB~~ 1:1000
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name NAA15
Synonyms GA19, NARG1, NATH, TBDN100
Function Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter.
Cellular Location Cytoplasm. Nucleus. Note=Mainly cytoplasmic, nuclear in some cases. Present in the free cytosolic and cytoskeleton-bound polysomes, but not in the membrane-bound polysomes
Tissue Location Expressed at high levels in testis and in ocular endothelial cells. Also found in brain (corpus callosum), heart, colon, bone marrow and at lower levels in most adult tissues, including thyroid, liver, pancreas, mammary and salivary glands, lung, ovary, urogenital system and upper gastrointestinal tract. Overexpressed in gastric cancer, in papillary thyroid carcinomas and in a Burkitt lymphoma cell line (Daudi) Specifically suppressed in abnormal proliferating blood vessels in eyes of patients with proliferative diabetic retinopathy
Research Areas

BACKGROUND

The NAA10-NAA15 complex displays alpha (N-terminal) acetyltransferase activity that may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter.

REFERENCES

Line A.,et al.Br. J. Cancer 86:1824-1830(2002).
Willis D.M.,et al.J. Biol. Chem. 277:37280-37291(2002).
Fluge O.,et al.Oncogene 21:5056-5068(2002).
He Y.G.,et al.Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 34:353-357(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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