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ES8L2 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - ES8L2 Antibody AP50687
    Western blot analysis of lysates from A431,HepG2 cell line (from left to right),using ES8L2 Antibody(AP50687). AP50687 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysates at 35ug per lane.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q9H6S3
Reactivity Human, Mouse
Host Rabbit
Clonality polyclonal
Calculated MW 81,37,82 KDa
Additional info
Gene ID 64787
Other Names Epidermal growth factor receptor kinase substrate 8-like protein 2, EPS8-like protein 2, Epidermal growth factor receptor pathway substrate 8-related protein 2, EPS8-related protein 2, EPS8L2, EPS8R2
Dilution WB~~ 1:1000
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name EPS8L2
Synonyms EPS8R2
Function Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity).
Cellular Location Cytoplasm. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q99K30} Note=Localizes at the tips of the stereocilia of the inner and outer hair cells. {ECO:0000250|UniProtKB:Q99K30}
Tissue Location Detected in fibroblasts and placenta.
Research Areas

BACKGROUND

Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton.

REFERENCES

Tocchetti A.,et al.Genomics 81:234-244(2003).
Wan D.,et al.Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Offenhaeuser N.,et al.Mol. Biol. Cell 15:91-98(2004).

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