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>   首页   >   产品   >   一抗   >   癌症   >   Cox1 Antibody   

Cox1 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - Cox1 Antibody AP50673
    Western blot analysis of lysate from A431 cell line,using Cox1 Antibody(AP50673). AP50673 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.
  • 1 - Cox1 Antibody AP50673
    Western blot analysis of extracts from HuvEc cells (Lane 2), using Cox1 Antibody. The lane on the left is treated with systhesized peptide.
  • 2 - Cox1 Antibody AP50673
    Immunohistochemical analysis of paraffin-embedded human brain tissue using COX1 antibody .
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC
Primary Accession P23219
Reactivity Human
Host Rabbit
Clonality polyclonal
Calculated MW 69 65 62 56 72 KDa
Additional info
Gene ID 5742
Other Names Prostaglandin G/H synthase 1, Cyclooxygenase-1, COX-1, Prostaglandin H2 synthase 1, PGH synthase 1, PGHS-1, PHS 1, Prostaglandin-endoperoxide synthase 1, PTGS1, COX1
Dilution WB~~1:1000
IHC~~1:50-1:100
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name PTGS1
Synonyms COX1
Function Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.
Cellular Location Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein
Research Areas

BACKGROUND

May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.

REFERENCES

Yokoyama C.,et al.Biochem. Biophys. Res. Commun. 165:888-894(1989).
Funk C.D.,et al.FASEB J. 5:2304-2312(1991).
Takahashi Y.,et al.Biochem. Biophys. Res. Commun. 182:433-438(1992).
Diaz A.,et al.J. Biol. Chem. 267:10816-10822(1992).
Scott B.T.,et al.Blood Coagul. Fibrinolysis 13:519-531(2002).

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