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>   首页   >   产品   >   一抗   >   免疫学   >   MX2 Antibody   

MX2 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - MX2 Antibody AP50672
    Western blot analysis of lysate from U266 cell line,using MX2 Antibody(AP50672). AP50672 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P20592
Reactivity Human
Host Rabbit
Clonality polyclonal
Calculated MW 82 KDa
Additional info
Gene ID 4600
Other Names Interferon-induced GTP-binding protein Mx2, Interferon-regulated resistance GTP-binding protein MxB, Myxovirus resistance protein 2, p78-related protein, MX2
Dilution WB~~1:1000
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name MX2
Function Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression.
Cellular Location Cytoplasm. Nucleus. Nucleus, nuclear pore complex. Note=Localization to nuclear pores requires GTP-binding
Research Areas

BACKGROUND

Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression.

REFERENCES

Aebi M.,et al.Mol. Cell. Biol. 9:5062-5072(1989).
Hattori M.,et al.Nature 405:311-319(2000).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Horisberger M.A.,et al.J. Virol. 64:1171-1181(1990).
King M.C.,et al.Proc. Natl. Acad. Sci. U.S.A. 101:8957-8962(2004).

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