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>   首页   >   产品   >   一抗   >   精选抗体   >   Granzyme B Antibody   

Granzyme B Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - Granzyme B Antibody AP50660
    Western blot analysis of lysate from human spleen tissue lysate,using Granzyme B Antibody(AP50660). AP50660 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.
  • 2 - Granzyme B Antibody AP50660
    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Granzyme B antibody .
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC
Primary Accession P10144
Other Accession P20718
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality polyclonal
Calculated MW 27,18,13 KDa
Additional info
Gene ID 3002
Other Names Granzyme B, C11, CTLA-1, Cathepsin G-like 1, CTSGL1, Cytotoxic T-lymphocyte proteinase 2, Lymphocyte protease, Fragmentin-2, Granzyme-2, Human lymphocyte protein, HLP, SECT, T-cell serine protease 1-3E, GZMB, CGL1, CSPB, CTLA1, GRB
Dilution WB~~1:1000
IHC~~1:50-1:100
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name GZMB
Synonyms CGL1, CSPB, CTLA1, GRB
Function This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
Cellular Location Cytoplasmic granule. Note=Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells
Research Areas

BACKGROUND

This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.

REFERENCES

Schmid J.,et al.J. Immunol. 139:250-256(1987).
Caputo A.,et al.J. Biol. Chem. 263:6363-6369(1988).
Trapani J.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:6924-6928(1988).
Klein J.L.,et al.Genomics 5:110-117(1989).
Caputo A.,et al.J. Immunol. 145:737-744(1990).

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