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>   首页   >   产品   >   一抗   >   心血管   >   ADRA2A Antibody   

ADRA2A Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - ADRA2A Antibody AP50657
    Western blot analysis of lysate from H.brain cell line,using ADRA2A Antibody(AP50657). AP50657 was diluted at 1:500. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.
  • 3 - ADRA2A Antibody AP50657
    Immunofluorescence analysis of LOVO cells, using ADRA2A antibody.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IF
Primary Accession P08913
Reactivity Human
Host Rabbit
Clonality polyclonal
Calculated MW 49 KDa
Additional info
Gene ID 150
Other Names Alpha-2A adrenergic receptor, Alpha-2 adrenergic receptor subtype C10, Alpha-2A adrenoreceptor, Alpha-2A adrenoceptor, Alpha-2AAR, ADRA2A, ADRA2R, ADRAR
Dilution WB~~1:500
IF~~1:100
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name ADRA2A
Synonyms ADRA2R, ADRAR
Function Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.
Cellular Location Cell membrane; Multi-pass membrane protein
Research Areas

BACKGROUND

Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.

REFERENCES

Kobilka B.K.,et al.Science 238:650-656(1987).
Fraser C.M.,et al.J. Biol. Chem. 264:11754-11761(1989).
Guyer C.A.,et al.J. Biol. Chem. 265:17307-17317(1990).
Small K.M.,et al.J. Biol. Chem. 275:38518-38523(2000).
Small K.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 103:5472-5477(2006).

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