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>   首页   >   产品   >   一抗   >   其他   >   DNA Polymerase β Antibody   

DNA Polymerase β Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - DNA Polymerase β Antibody AP50642
    Western blot analysis of lysates from A431,Jurkat cell line (from left to right),using DNA Polymerase β Antibody(AP50642). AP50642 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysates at 35ug per lane.
  • 2 - DNA Polymerase β Antibody AP50642
    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using DNA Polymerase β antibody .
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC
Primary Accession P06746
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality polyclonal
Calculated MW 38 KDa
Additional info
Gene ID 5423
Other Names DNA polymerase beta, 4299-, POLB
Dilution WB~~1:1000
IHC~~1:50-1:100
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name POLB
Function Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.
Cellular Location Nucleus. Cytoplasm. Note=Cytoplasmic in normal conditions. Translocates to the nucleus following DNA damage
Research Areas

BACKGROUND

Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.

REFERENCES

Patterson T.A.,et al.Protein Expr. Purif. 18:100-110(2000).
Dobashi Y.,et al.Hum. Genet. 95:389-390(1995).
Chyan Y.-J.,et al.Nucleic Acids Res. 22:2719-2725(1994).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.

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