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>   首页   >   产品   >   一抗   >   信号转导   >   Claudin 1 Antibody   

Claudin 1 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - Claudin 1 Antibody AP50636
    Western blot analysis of lysates from A431,ZR-75-1 cell line (from left to right),using Claudin 1 Antibody(AP50636). AP50636 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysates at 35ug per lane.
  • 1 - Claudin 1 Antibody AP50636
    Western blot analysis of extracts from 293 cells (Lane 2), using Claudin 1 Antibody. The lane on the left is treated with synthesized peptide.
  • 2 - Claudin 1 Antibody AP50636
    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Claudin 1 antibody .
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC
Primary Accession O95832
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality polyclonal
Calculated MW 23 KDa
Additional info
Gene ID 9076
Other Names Claudin-1, Senescence-associated epithelial membrane protein, CLDN1, CLD1, SEMP1
Dilution WB~~1:1000
IHC~~1:50-1:100
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name CLDN1
Synonyms CLD1, SEMP1
Function Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391). CLDN1 acts as a coreceptor for HCV entry into hepatic cells.
Cellular Location Cell junction, tight junction. Cell membrane; Multi-pass membrane protein
Tissue Location Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis
Research Areas

BACKGROUND

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells.

REFERENCES

Swisshelm K.L.,et al.Gene 226:285-295(1999).
Mitic L.M.,et al.Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
Halford S.,et al.Cytogenet. Cell Genet. 88:217-217(2000).
Kraemer F.,et al.Hum. Genet. 107:249-256(2000).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).

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